Clinical Exploration of Medicines used in the Patient with Nephrotic Disorders and its Consequence on Endocrine Function

The massive losses of albumin and hormone-binding proteins are responsible for metabolic derangements with endocrine abnormalities in nephrotic patients. A Population-based longitudinal study in north Indian hospitals for risk factor of cardiac remodeling appropriate to the prescription of anti-nephrotic drugs on 87 nephrotic patients were observed during the clinical survey. The kidney function test, lipid profile and thyroid profile with vitamin-D has been recommended for all patients. The laboratory values such as SGOP (25.80±10.86 IU), SGPT (22.72±13.50 IU) and GGTP (57.58±89.27 IU) were merely elevated in comparison to normal values and confirms the disturbance in liver function. Serum Protein (6.87±7.47 gm/dl), Serum Albumin (3.78±1.11 gm/dl), Serum Globulin (3.34±0.96 gm/dl) and 24 Hour Protein (2950.30±1856.94 mg) confirmed the demolition in the liver enzyme. The elevated levels of urinary profile confirm that all patients have been suffering from kidney disorders, which influence the cardiac function because of the accumulation of creatinine and urinary protein in the body. The deficiency of vitamin D plays a vital role in cardiac remodeling, which is maintained by the normal and routine function of the kidney.

Keywords: Nephrotic disorder, Kidney, Creatinine, Vitamin D, Albumin, Endocrine.